Desmosome-Dyad Crosstalk
نویسندگان
چکیده
منابع مشابه
The desmosome.
Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit intermediate filaments to sites of desmosome assem...
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Pemphigus (from the Greek pemphix, meaning bubble or blister) is a blistering disease involving the skin and mucous membrane. The disease is characterized histologically by acantholysis which means loss of adhesion between keratinocytes, and immuno-pathologically by the presence of immunoglobulin directed towards the cell surface of kerat inocytes . 1 The landmark ar t ic le in the understandin...
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The skin is subjected to continuous physical stress. Keratinocytes resist mechanical stress by tethering the tension-bearing keratin intermediate filament cytoskeleton to sites of intercellular contact known as desmosomes (Garrod and Chidgey, 2008; Green and Simpson, 2007). The plakin protein desmoplakin (DP) is an obligate desmosomal constituent necessary for keratin anchorage at cell-cell con...
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During the pupal stage of moths, a mass of connective tissue develops on the dorsal side of the abdominal nerve cord . The cells, which secrete the fibrous matrix, are originally close together, but as they secrete the matrix, they are pushed apart, with a corresponding decrease in their size . As the process proceeds, it was noticed that there is a gradual development of desmosomes where the m...
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In the corneal epithelium of the embryonic chick there is a 3- to 4-fold increase in desmosomes between the 15th and 16th days of incubation which has not been noted in earlier studies of this tissue. This finding has made it feasible to study the effects of the local cell environment on desmosome formation. Cells of 15-day corneas which were forming desmosomes rapidly, were dispersed and combi...
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ژورنال
عنوان ژورنال: Circulation
سال: 2020
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.120.046020